Endocrine Abstracts

Introduction: Heart failure with preserved ejection fraction (HFpEF) is a clinical syndrome with high mortality, for which there are few disease modifying therapeutics. Thyroid axis dysfunction is common in heart failure (HF) and may contribute to the pathogenesis of HFpEF. However, the association of thyroid hormones (TH) with the clinical status of HFpEF patients and their prognostic impact in this syndrome are not clear. Methods: We evaluated 93 parti...

The tumor immune microenvironment is essential, it could influence a favorable or negative response against the tumor cells, and it has been related to therapy response and prognostic factors. Tumor infiltrating lymphocytes (TILs) plays an important role in the development, progression, and tumor control, thus presence of TILs could be related to disease-specific traits. The aim of the present work is to evaluate the expression of immune-related genes in forty-two pituitary ad...

Our previous study showed that polycystic ovary syndrome (PCOS)-like reproductive and metabolic phenotypes induced by maternal dihydrotestosterone (DHT)-exposure, can be passed on in mice from mothers (F0) to daughters (F1), granddaughters (F2), and even to great-granddaughters (F3). The female transmission is independent of diet-induced obesity and is mediated by transcriptional and mitochondrial perturbations of oocytes accompany. ...

Introduction: Insulinoma, despite its low incidence of 0.4%, it is the most common functioning pancreatic neuroendocrine tumor. Most are benign, solitary and sporadic. Around 10% can be malignant and 5-10% are part of MEN-1. On certain occasions, the differential diagnosis is difficult when there is a history of Diabetes Mellitus (DM). Our objective was to describe clinical-epidemiological data and its diagnostic-therapeutic management.Materials and Meth...

The tumor microenvironment (TME) includes diverse cellular components such as mesenchymal stem cells (MSC) and immune cells. MSC are a subset of heterogeneous cell populations characterized by the expression of CD105, CD73, and CD90 that can differentiate into chondrocytes, osteoblasts, and adipocytes in vitro. They are known to have immunomodulatory capabilities. Our aim was to isolate and characterize the immunomodulatory capabilities of MSC from pituitary tumors (P...

Pheochromocytomas and paragangliomas (PPGLs) are rare neuroendocrine neoplasms (NENs) that arise in the adrenal medulla and paraganglia, respectively. As occurs in the rest of NENs, PPGLs commonly present a high density of somatostatin receptors (SSTs) on their membrane. However, unlike in most NENs, somatostatin analogues (SSAs) do not represent a suitable therapeutic target in PPGLs, and the mechanisms underlying this mismatch are still unclear. In this study, we aim to iden...

Introduction: Non-alcoholic fatty liver disease (NAFLD) and Heart Failure with Preserved Ejection Fraction (HFpEF) are two syndromes with increasing clinical relevance, mainly due to the rising prevalence of metabolic syndrome. Despite sharing a common metabolic background, the association between NAFLD severity and HFpEF has not yet been well explored.Aim: To evaluate the association of NAFLD steatosis and fibrosis scores with cardiovascular function an...

Pheochromocytomas and paragangliomas (PPGL) are infrequent neuroendocrine neoplasms, which develop metastases or aggressive behaviour in 25 % patients. They can be classified into three clusters according to their molecular features; nevertheless, these differences may not stratify patients according to their prognosis. The dysregulation of the splicing process has emerged as a novel feature shared by most cancers, which is associated with an aggressive phenotype in several tu...

Background: The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic disease (Covid-19) is associated with the onset of thyroid dysfunction via multiple mechanisms. Patients hospitalised for severe Covid-19 disease may develop painless atypical thyroiditis coexisting with non-thyroidal illness syndrome, which determines transient thyrotoxicosis with quick restoration of euthyroidism during the following weeks. However signs of thyroiditis at ultrasound and sci...

In Wuhan China in December 2019, cases of severe atypical viral pneumonia emerged, and the World Health Organization declared COVID-19 a pandemic. In this critical context, health workers were on the front lines, directly participating in the evaluation, diagnosis, and treatment of patients with COVID-19. The objective of our work was to evaluate stress and burnout in health workers and to measure hair cortisol levels as a stress biomarker during the second wave.<p class="...